All talks start at 7.30pm in the Royal Society of Edinburgh, 22 - 26 George Street, with refreshments from 7.00 pm
Abstract: Raman spectroscopy has been demonstrated across many clinical applications to be a powerful tool for the biochemical discrimination of disease. Translation of this technique to the clinic and enabling its use within the body is a difficult but achievable prospect.
Rapid, minimally invasive, in vivo molecular diagnosis would provide clinicians for a powerful tool. There are myriad clinical needs where
such an approach would add significant value. These range from early diagnosis of malignancies on the linings of organs, to staging more
advanced malignancies, to providing treatment monitoring, tumour margin, lymph node metastasis status and of course the prospect for
prognostic signature identification. Work over many years has taken the concept of in vivo Raman diagnostics to real clinical studies. A
number of groups are now using the technique in vivo for the study of tissue composition and its association with diseased conditions. I will
give an overview of some of our current work in the area.
This presentation will focus on a range of approaches:
1) Surface based analysis of disease specific tissue composition utilising endoscopic confocal Raman probes; 
2) Subcutaneous analysis using needle Raman probes; 
3) Deep Raman analysis of tissue composition with transmission and spatially offset approaches. 
4) The potential of plasmonic nanostructures to enhance medical diagnostics/therapeutics.
1 J C C Day et al, Phys. Med. Biol., 2009, 54 7077-7087.
2 J Day, N Stone, Applied Spectroscopy, 2013, 67 (3), 349-354.
3 P Matousek, N Stone, J. Biophotonics, 2013, 6 (1), 7-19,